Comprehensive Biochemistry I (BC 401) covers the structural biochemistry of nucleic acids, proteins, and lipids at an advanced level. Unit 1 goes through the biochemical alphabet: thermodynamics, water, the hydrophobic effect, and non-covalent interactions. Unit 2 addresses key structural aspects of DNA and RNA. Unit 3 covers the fundamentals of protein architecture: primary, secondary, and tertiary structure. Unit 4 is dedicated to protein structure/function relationships, and includes specific topics such as myoglobin/hemoglobin, enzymes, membranes and membrane proteins, and protein-DNA interactions. The course ends with Unit 5, which describes the structure and function of macromolecular assemblages such as bacterial chaperones, ATP synthase, the ribosome, and the nucleosome.
Upon the completion of BC 401, a successful student will be able to describe and discuss the:
- non-covalent interactions found in nucleic acids, proteins and lipids.
- molecular architecture of nucleic acids.
- molecular architecture of proteins.
- molecular architecture of macromolecular assemblages.
This course requires proctored exams. Details will be provided in the course syllabus.
CHEM 245 (Fundamentals of Organic Chemistry) or CHEM 343 (Modern Organic Chemistry II) or concurrent registration or CHEM 346 (Organic Chemistry II) or concurrent registration; MATH 155 (Calculus for Biological Scientists I) or MATH 160 (Calculus for Physical Scientists I).
Jeffrey C. Hansen is a Professor and Associate Chair for Undergraduate Studies in the Department of Biochemistry and Molecular Biology at Colorado State University. His research interests focus on biochemical and biophysical approaches to studying chromatin and chromosomes. He teaches undergraduate courses in the structural biochemistry of nucleic acids, proteins, and lipids, and lectures about chromatin and chromosomes to graduate students. He has recently helped developed interactive online tutorials for use in structural biochemistry courses, for which he received the Chancellor’s Preston Davis Award for Instructional Innovation from CSU in 2018.