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The structure of the course is based on the organization of the eukaryotic cell from exterior membranes and cell ultrastructure to information storage in the nucleus, through the expression of genetic information via transcription and translation and protein processing and localization, and ending with cell signaling and its relationship to gene expression and immunological responses. Examples highlight interference at any of these junctures by bacteria and viruses and the relation of such molecular interference to disease outcome at cellular and organismal levels.
The core of the course will be the understanding of host and infectious agent molecular processes as well as methods of analysis of these mechanisms, eg. genomics, transcriptomics and proteomics. These approaches are coupled with methods for nucleic acid, protein, and cell analyses that are critical for research investigations.
Upon the completion of this course, students will be able to: